Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

Steelman, L S

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. [electronic resource] - Oncogene Jul 2008 - 4086-95 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-5594

10.1038/onc.2008.49 doi


Amino Acid Substitution
Antibiotics, Antineoplastic--agonists
Breast Neoplasms--drug therapy
Cell Line, Tumor
Doxorubicin--agonists
Drug Resistance, Neoplasm--drug effects
Drug Synergism
Female
Gene Expression
Humans
Mutation, Missense
PTEN Phosphohydrolase--antagonists & inhibitors
Protein Kinases--genetics
Proto-Oncogene Proteins c-akt--genetics
Ribosomal Protein S6 Kinases, 70-kDa--genetics
Signal Transduction--drug effects
Sirolimus--agonists
TOR Serine-Threonine Kinases
Transfection