Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors. [electronic resource]
Producer: 20080609Description: 2194-7 p. digitalISSN:- 1464-3405
- Allosteric Site
- Animals
- Apoptosis -- drug effects
- Caspases -- metabolism
- Dogs
- Humans
- Male
- Metabolic Clearance Rate
- Molecular Structure
- Prostatic Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- chemical synthesis
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Pyridines -- chemistry
- Structure-Activity Relationship
- TNF-Related Apoptosis-Inducing Ligand -- pharmacology
- Tumor Cells, Cultured
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Publication Type: Journal Article
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