Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.

Hartnett, John C

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors. [electronic resource] - Bioorganic & medicinal chemistry letters Mar 2008 - 2194-7 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2007.12.040 doi


Allosteric Site
Animals
Apoptosis--drug effects
Caspases--metabolism
Dogs
Humans
Male
Metabolic Clearance Rate
Molecular Structure
Prostatic Neoplasms--drug therapy
Protein Kinase Inhibitors--chemical synthesis
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Pyridines--chemistry
Structure-Activity Relationship
TNF-Related Apoptosis-Inducing Ligand--pharmacology
Tumor Cells, Cultured