Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. [electronic resource]
Producer: 20080515Description: 3907-16 p. digitalISSN:- 1464-3391
- Binding Sites
- Blood Platelets -- drug effects
- Cyclooxygenase 2 -- chemistry
- Cyclooxygenase 2 Inhibitors -- chemical synthesis
- Drug Design
- Fluorine Compounds -- chemical synthesis
- Humans
- Hydrogen Bonding
- Indoles -- chemistry
- Lipoxygenase Inhibitors -- chemical synthesis
- Magnetic Resonance Spectroscopy
- Methylation
- Models, Molecular
- Molecular Structure
- Pyrazoles -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
- Sulfur Compounds -- chemical synthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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