Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Reddy, M V Ramana
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. [electronic resource] - Bioorganic & medicinal chemistry Apr 2008 - 3907-16 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1464-3391
10.1016/j.bmc.2008.01.047 doi
Binding Sites
Blood Platelets--drug effects
Cyclooxygenase 2--chemistry
Cyclooxygenase 2 Inhibitors--chemical synthesis
Drug Design
Fluorine Compounds--chemical synthesis
Humans
Hydrogen Bonding
Indoles--chemistry
Lipoxygenase Inhibitors--chemical synthesis
Magnetic Resonance Spectroscopy
Methylation
Models, Molecular
Molecular Structure
Pyrazoles--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Sulfur Compounds--chemical synthesis
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. [electronic resource] - Bioorganic & medicinal chemistry Apr 2008 - 3907-16 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1464-3391
10.1016/j.bmc.2008.01.047 doi
Binding Sites
Blood Platelets--drug effects
Cyclooxygenase 2--chemistry
Cyclooxygenase 2 Inhibitors--chemical synthesis
Drug Design
Fluorine Compounds--chemical synthesis
Humans
Hydrogen Bonding
Indoles--chemistry
Lipoxygenase Inhibitors--chemical synthesis
Magnetic Resonance Spectroscopy
Methylation
Models, Molecular
Molecular Structure
Pyrazoles--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Sulfur Compounds--chemical synthesis