Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. [electronic resource]
Producer: 20080509Description: 628-37 p. digitalISSN:- 0002-9440
- Animals
- Aptamers, Nucleotide -- therapeutic use
- Cell Count
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Cells, Cultured
- Chemokine CCL2 -- antagonists & inhibitors
- Diabetes Mellitus, Type 1 -- complications
- Diabetic Nephropathies -- prevention & control
- Glomerular Filtration Rate -- drug effects
- Kidney -- drug effects
- Macrophages -- drug effects
- Male
- Mice
- Mice, Inbred NOD
- Nephrectomy
- Nephritis, Interstitial -- etiology
- RNA, Messenger -- metabolism
- Receptors, CCR2 -- metabolism
- Time Factors
- Transforming Growth Factor beta -- metabolism
No physical items for this record
Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
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