Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.

Ninichuk, Volha

Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. [electronic resource] - The American journal of pathology Mar 2008 - 628-37 p. digital

Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

0002-9440

10.2353/ajpath.2008.070601 doi


Animals
Aptamers, Nucleotide--therapeutic use
Cell Count
Cell Movement--drug effects
Cell Proliferation--drug effects
Cells, Cultured
Chemokine CCL2--antagonists & inhibitors
Diabetes Mellitus, Type 1--complications
Diabetic Nephropathies--prevention & control
Glomerular Filtration Rate--drug effects
Kidney--drug effects
Macrophages--drug effects
Male
Mice
Mice, Inbred NOD
Nephrectomy
Nephritis, Interstitial--etiology
RNA, Messenger--metabolism
Receptors, CCR2--metabolism
Time Factors
Transforming Growth Factor beta--metabolism