The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding. [electronic resource]
Producer: 20080520Description: 669-76 p. digitalISSN:- 1538-7836
- Animals
- Bleeding Time
- Collagen -- antagonists & inhibitors
- Crotalid Venoms -- antagonists & inhibitors
- Dipeptides -- pharmacology
- Humans
- Lectins, C-Type -- antagonists & inhibitors
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases -- physiology
- Molecular Weight
- Phosphorylation -- drug effects
- Platelet Activation -- drug effects
- Platelet Aggregation -- drug effects
- Platelet Glycoprotein GPIIb-IIIa Complex
- Platelet Membrane Glycoproteins -- agonists
- Platelet-Rich Plasma
- Protein Binding
- Protein Processing, Post-Translational -- drug effects
- Protein Subunits
- Signal Transduction -- drug effects
- Viperidae -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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