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The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding.

Chang, C-H

The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding. [electronic resource] - Journal of thrombosis and haemostasis : JTH Apr 2008 - 669-76 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 1538-7836

Standard No.: 10.1111/j.1538-7836.2008.02914.x doi

Subjects--Topical Terms:
Animals
Bleeding Time
Collagen--antagonists & inhibitors
Crotalid Venoms--antagonists & inhibitors
Dipeptides--pharmacology
Humans
Lectins, C-Type--antagonists & inhibitors
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases--physiology
Molecular Weight
Phosphorylation--drug effects
Platelet Activation--drug effects
Platelet Aggregation--drug effects
Platelet Glycoprotein GPIIb-IIIa Complex
Platelet Membrane Glycoproteins--agonists
Platelet-Rich Plasma
Protein Binding
Protein Processing, Post-Translational--drug effects
Protein Subunits
Signal Transduction--drug effects
Viperidae--metabolism