IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. [electronic resource]
Producer: 20080716Description: 4723-30 p. digitalISSN:- 1528-0020
- Antibodies, Monoclonal -- pharmacology
- Antibodies, Monoclonal, Murine-Derived
- Antibody-Dependent Cell Cytotoxicity
- Apoptosis
- Apoptosis Regulatory Proteins -- genetics
- Bcl-2-Like Protein 11
- Cytotoxicity, Immunologic
- Humans
- Interleukins -- physiology
- Membrane Proteins -- genetics
- Proto-Oncogene Proteins -- genetics
- Rituximab
- STAT1 Transcription Factor -- metabolism
- STAT5 Transcription Factor -- metabolism
- Up-Regulation -- genetics
- Vidarabine -- analogs & derivatives
- Interleukin-21
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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