IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro.

Gowda, Aruna

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. [electronic resource] - Blood May 2008 - 4723-30 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0020

10.1182/blood-2007-07-099531 doi


Antibodies, Monoclonal--pharmacology
Antibodies, Monoclonal, Murine-Derived
Antibody-Dependent Cell Cytotoxicity
Apoptosis
Apoptosis Regulatory Proteins--genetics
Bcl-2-Like Protein 11
Cytotoxicity, Immunologic
Humans
Interleukins--physiology
Membrane Proteins--genetics
Proto-Oncogene Proteins--genetics
Rituximab
STAT1 Transcription Factor--metabolism
STAT5 Transcription Factor--metabolism
Up-Regulation--genetics
Vidarabine--analogs & derivatives
Interleukin-21