Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. [electronic resource]
Producer: 20080513Description: 4173-83 p. digitalISSN:- 0006-4971
- Cholesterol -- deficiency
- Enzyme Activation -- drug effects
- Humans
- Immunoglobulin G -- pharmacology
- Interferon-gamma -- biosynthesis
- Interleukin-12 -- pharmacology
- Intracellular Signaling Peptides and Proteins -- metabolism
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Killer Cells, Natural -- cytology
- Membrane Microdomains -- enzymology
- Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors
- Phosphatidylinositol 3-Kinases -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein Transport -- drug effects
- Protein-Tyrosine Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptors, IgG -- immunology
- Receptors, Interleukin-12 -- immunology
- STAT4 Transcription Factor -- metabolism
- Syk Kinase
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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