Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma.

Kondadasula, Sri Vidya

Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. [electronic resource] - Blood Apr 2008 - 4173-83 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0006-4971

10.1182/blood-2007-01-068908 doi


Cholesterol--deficiency
Enzyme Activation--drug effects
Humans
Immunoglobulin G--pharmacology
Interferon-gamma--biosynthesis
Interleukin-12--pharmacology
Intracellular Signaling Peptides and Proteins--metabolism
JNK Mitogen-Activated Protein Kinases--metabolism
Killer Cells, Natural--cytology
Membrane Microdomains--enzymology
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Phosphatidylinositol 3-Kinases--metabolism
Protein Kinase Inhibitors--pharmacology
Protein Transport--drug effects
Protein-Tyrosine Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Receptors, IgG--immunology
Receptors, Interleukin-12--immunology
STAT4 Transcription Factor--metabolism
Syk Kinase
p38 Mitogen-Activated Protein Kinases--metabolism