Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. [electronic resource]
Producer: 20080519Description: 209-14 p. digitalISSN:- 0091-2700
- Area Under Curve
- Cells, Cultured
- Chromatography, Liquid
- Cross-Over Studies
- Cytochrome P-450 CYP3A -- genetics
- Dose-Response Relationship, Drug
- Drug Interactions
- Female
- HIV Integrase Inhibitors -- pharmacology
- Half-Life
- Hepatocytes -- cytology
- Humans
- Male
- Mass Spectrometry
- Metabolic Clearance Rate
- Microsomes, Liver -- drug effects
- Midazolam -- administration & dosage
- Organic Chemicals -- pharmacology
- Pyrrolidinones
- Raltegravir Potassium
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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