Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation.

Iwamoto, Marian

Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. [electronic resource] - Journal of clinical pharmacology Feb 2008 - 209-14 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

0091-2700

10.1177/0091270007310382 doi


Area Under Curve
Cells, Cultured
Chromatography, Liquid
Cross-Over Studies
Cytochrome P-450 CYP3A--genetics
Dose-Response Relationship, Drug
Drug Interactions
Female
HIV Integrase Inhibitors--pharmacology
Half-Life
Hepatocytes--cytology
Humans
Male
Mass Spectrometry
Metabolic Clearance Rate
Microsomes, Liver--drug effects
Midazolam--administration & dosage
Organic Chemicals--pharmacology
Pyrrolidinones
Raltegravir Potassium
Reverse Transcriptase Polymerase Chain Reaction