An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells. [electronic resource]
Producer: 20080519Description: 332-47 p. digitalISSN:- 0009-2797
- Apoptosis -- drug effects
- Caspase 8 -- biosynthesis
- Caspase 9 -- drug effects
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- Cymbopogon -- chemistry
- Cytochromes c -- biosynthesis
- DNA -- drug effects
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- HL-60 Cells
- Humans
- Leukemia, Promyelocytic, Acute -- drug therapy
- Mitochondria -- drug effects
- Molecular Conformation
- NF-kappa B -- biosynthesis
- Oils, Volatile -- chemistry
- Reactive Oxygen Species -- metabolism
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- Receptors, Tumor Necrosis Factor -- biosynthesis
- Receptors, Tumor Necrosis Factor, Type I -- biosynthesis
- Sesquiterpenes -- chemistry
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- bcl-2-Associated X Protein -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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