An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells.

Kumar, Ajay

An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells. [electronic resource] - Chemico-biological interactions Feb 2008 - 332-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0009-2797

10.1016/j.cbi.2007.10.003 doi


Apoptosis--drug effects
Caspase 8--biosynthesis
Caspase 9--drug effects
Cell Cycle--drug effects
Cell Proliferation--drug effects
Cymbopogon--chemistry
Cytochromes c--biosynthesis
DNA--drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Leukemia, Promyelocytic, Acute--drug therapy
Mitochondria--drug effects
Molecular Conformation
NF-kappa B--biosynthesis
Oils, Volatile--chemistry
Reactive Oxygen Species--metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor--biosynthesis
Receptors, Tumor Necrosis Factor, Type I--biosynthesis
Sesquiterpenes--chemistry
Signal Transduction--drug effects
Tumor Cells, Cultured
bcl-2-Associated X Protein--drug effects