1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism. [electronic resource]
Producer: 20080205Description: 7431-8 p. digitalISSN:- 0022-1767
- ADP Ribose Transferases
- Acute Disease
- Adenosine A2 Receptor Antagonists
- Animals
- Bacterial Toxins
- Caffeine -- blood
- Chemical and Drug Induced Liver Injury -- immunology
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Exotoxins
- Female
- Liver -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phosphodiesterase Inhibitors -- blood
- Receptor, Adenosine A2A -- genetics
- Virulence Factors
- Pseudomonas aeruginosa Exotoxin A
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
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