Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene. [electronic resource]
Producer: 20080522Description: 865-72 p. digitalISSN:- 0145-2126
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
- Apoptosis -- drug effects
- Benzimidazoles -- therapeutic use
- Cell Proliferation -- drug effects
- Female
- Humans
- Indoles -- therapeutic use
- Leukemia -- drug therapy
- Leukemia, Megakaryoblastic, Acute -- drug therapy
- Leukemia, Myeloid, Acute -- drug therapy
- MAP Kinase Kinase 1 -- antagonists & inhibitors
- Male
- Middle Aged
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors
- Mutation -- genetics
- Pyrroles -- therapeutic use
- Ribosomal Protein S6 Kinases, 70-kDa -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Sunitinib
- Tumor Cells, Cultured
- fms-Like Tyrosine Kinase 3 -- genetics
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
There are no comments on this title.
Log in to your account to post a comment.