Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.
Nishioka, Chie
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene. [electronic resource] - Leukemia research Jun 2008 - 865-72 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0145-2126
10.1016/j.leukres.2007.09.017 doi
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Apoptosis--drug effects
Benzimidazoles--therapeutic use
Cell Proliferation--drug effects
Female
Humans
Indoles--therapeutic use
Leukemia--drug therapy
Leukemia, Megakaryoblastic, Acute--drug therapy
Leukemia, Myeloid, Acute--drug therapy
MAP Kinase Kinase 1--antagonists & inhibitors
Male
Middle Aged
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Mutation--genetics
Pyrroles--therapeutic use
Ribosomal Protein S6 Kinases, 70-kDa--antagonists & inhibitors
Signal Transduction--drug effects
Sunitinib
Tumor Cells, Cultured
fms-Like Tyrosine Kinase 3--genetics
Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene. [electronic resource] - Leukemia research Jun 2008 - 865-72 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0145-2126
10.1016/j.leukres.2007.09.017 doi
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Apoptosis--drug effects
Benzimidazoles--therapeutic use
Cell Proliferation--drug effects
Female
Humans
Indoles--therapeutic use
Leukemia--drug therapy
Leukemia, Megakaryoblastic, Acute--drug therapy
Leukemia, Myeloid, Acute--drug therapy
MAP Kinase Kinase 1--antagonists & inhibitors
Male
Middle Aged
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Mutation--genetics
Pyrroles--therapeutic use
Ribosomal Protein S6 Kinases, 70-kDa--antagonists & inhibitors
Signal Transduction--drug effects
Sunitinib
Tumor Cells, Cultured
fms-Like Tyrosine Kinase 3--genetics