Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. [electronic resource]
Producer: 20071127Description: 17204-9 p. digitalISSN:- 0027-8424
- Animals
- Behavior, Animal -- drug effects
- Cerebral Cortex -- drug effects
- Cholesterol -- metabolism
- Dependovirus
- Disease Models, Animal
- Gene Silencing
- Genetic Therapy
- Humans
- Huntingtin Protein
- Huntington Disease -- pathology
- Injections
- Intranuclear Inclusion Bodies -- drug effects
- Mice
- Motor Neuron Disease -- pathology
- Mutant Proteins -- antagonists & inhibitors
- Neostriatum -- drug effects
- Nerve Tissue Proteins -- antagonists & inhibitors
- Neurons -- pathology
- Neuropil Threads -- drug effects
- Nuclear Proteins -- antagonists & inhibitors
- RNA, Small Interfering -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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