Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. [electronic resource]
Producer: 20071107Description: 29230-40 p. digitalISSN:- 0021-9258
- Benzenesulfonates -- pharmacology
- Cell Line
- Cell Line, Tumor
- Cell Proliferation
- Humans
- Inhibitory Concentration 50
- Lysosomes -- metabolism
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Multiple Endocrine Neoplasia Type 2a -- metabolism
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Phosphorylation
- Proteasome Endopeptidase Complex -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins B-raf -- metabolism
- Proto-Oncogene Proteins c-ret -- metabolism
- Pyridines -- pharmacology
- Sorafenib
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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