Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.

Plaza-Menacho, Iván

Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. [electronic resource] - The Journal of biological chemistry Oct 2007 - 29230-40 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M703461200 doi


Benzenesulfonates--pharmacology
Cell Line
Cell Line, Tumor
Cell Proliferation
Humans
Inhibitory Concentration 50
Lysosomes--metabolism
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Multiple Endocrine Neoplasia Type 2a--metabolism
Niacinamide--analogs & derivatives
Phenylurea Compounds
Phosphorylation
Proteasome Endopeptidase Complex--metabolism
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins B-raf--metabolism
Proto-Oncogene Proteins c-ret--metabolism
Pyridines--pharmacology
Sorafenib