Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. [electronic resource]
Producer: 20071109Description: 3591-600 p. digitalISSN:- 1059-1524
- Ammonium Chloride -- pharmacology
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Protein Precursor -- chemistry
- Benzamides
- Cell Line, Tumor
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Imatinib Mesylate
- Models, Biological
- Neprilysin -- genetics
- Nerve Tissue Proteins -- metabolism
- Nuclear Proteins -- metabolism
- Peptide Fragments -- metabolism
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Protein Structure, Tertiary
- Pyrimidines -- pharmacology
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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