Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.

Eisele, Yvonne S

Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. [electronic resource] - Molecular biology of the cell Sep 2007 - 3591-600 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1059-1524

10.1091/mbc.e07-01-0035 doi


Ammonium Chloride--pharmacology
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Protein Precursor--chemistry
Benzamides
Cell Line, Tumor
Dose-Response Relationship, Drug
Gene Expression Regulation, Neoplastic--drug effects
Humans
Imatinib Mesylate
Models, Biological
Neprilysin--genetics
Nerve Tissue Proteins--metabolism
Nuclear Proteins--metabolism
Peptide Fragments--metabolism
Piperazines--pharmacology
Protein Kinase Inhibitors--pharmacology
Protein Structure, Tertiary
Pyrimidines--pharmacology
Up-Regulation--drug effects