Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. [electronic resource]
Producer: 20071015Description: 3515-27 p. digitalISSN:- 0022-2623
- Analgesics -- chemical synthesis
- Animals
- Benzothiazoles -- chemical synthesis
- CHO Cells
- Calcium -- metabolism
- Cricetinae
- Cricetulus
- Dogs
- Drug Stability
- Haplorhini
- Humans
- Hyperalgesia -- drug therapy
- In Vitro Techniques
- Inflammation -- drug therapy
- Male
- Microsomes, Liver -- metabolism
- Pain Measurement
- Pyrimidines -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Solubility
- Structure-Activity Relationship
- TRPV Cation Channels -- antagonists & inhibitors
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Publication Type: Journal Article
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