Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. [electronic resource]
Producer: 20071102Description: 1400-7 p. digitalISSN:- 0090-9556
- Animals
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Biological Transport -- drug effects
- Bosentan
- CHO Cells
- Cricetinae
- Cricetulus
- Cyclosporine -- pharmacology
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Dehydroepiandrosterone Sulfate -- metabolism
- Drug Interactions
- Enzyme Inhibitors -- pharmacology
- Estradiol -- analogs & derivatives
- Estrone -- analogs & derivatives
- Humans
- Liver-Specific Organic Anion Transporter 1
- Molecular Structure
- Organic Anion Transporters -- antagonists & inhibitors
- Organic Anion Transporters, Sodium-Independent -- antagonists & inhibitors
- Piperazines -- pharmacology
- Purines -- pharmacology
- Pyrimidines -- chemistry
- Rifampin -- pharmacology
- Sildenafil Citrate
- Solute Carrier Organic Anion Transporter Family Member 1B3
- Sulfonamides -- chemistry
- Sulfones -- pharmacology
- Warfarin -- metabolism
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Publication Type: Journal Article
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