Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.

Treiber, Alexander

Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Aug 2007 - 1400-7 p. digital

Publication Type: Journal Article

0090-9556

10.1124/dmd.106.013615 doi


Animals
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biological Transport--drug effects
Bosentan
CHO Cells
Cricetinae
Cricetulus
Cyclosporine--pharmacology
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--metabolism
Dehydroepiandrosterone Sulfate--metabolism
Drug Interactions
Enzyme Inhibitors--pharmacology
Estradiol--analogs & derivatives
Estrone--analogs & derivatives
Humans
Liver-Specific Organic Anion Transporter 1
Molecular Structure
Organic Anion Transporters--antagonists & inhibitors
Organic Anion Transporters, Sodium-Independent--antagonists & inhibitors
Piperazines--pharmacology
Purines--pharmacology
Pyrimidines--chemistry
Rifampin--pharmacology
Sildenafil Citrate
Solute Carrier Organic Anion Transporter Family Member 1B3
Sulfonamides--chemistry
Sulfones--pharmacology
Warfarin--metabolism