Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. [electronic resource]
Producer: 20070607Description: 713-25 p. digitalISSN:- 1534-5807
- Aurora Kinase B
- Aurora Kinases
- CDC2 Protein Kinase -- metabolism
- Catalysis -- drug effects
- Cell Cycle Proteins -- antagonists & inhibitors
- Chromosomes, Human -- genetics
- Cytokinesis -- drug effects
- Enzyme Activation -- drug effects
- Guanine Nucleotide Exchange Factors -- metabolism
- HeLa Cells
- Humans
- Microtubule-Associated Proteins -- metabolism
- Models, Biological
- Protein Binding -- drug effects
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein Transport -- drug effects
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Pteridines -- pharmacology
- Rho Guanine Nucleotide Exchange Factors
- Spindle Apparatus -- drug effects
- rhoA GTP-Binding Protein -- metabolism
- Polo-Like Kinase 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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