Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.

Petronczki, Mark

Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. [electronic resource] - Developmental cell May 2007 - 713-25 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1534-5807

10.1016/j.devcel.2007.03.013 doi


Aurora Kinase B
Aurora Kinases
CDC2 Protein Kinase--metabolism
Catalysis--drug effects
Cell Cycle Proteins--antagonists & inhibitors
Chromosomes, Human--genetics
Cytokinesis--drug effects
Enzyme Activation--drug effects
Guanine Nucleotide Exchange Factors--metabolism
HeLa Cells
Humans
Microtubule-Associated Proteins--metabolism
Models, Biological
Protein Binding--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein Transport--drug effects
Proto-Oncogene Proteins--antagonists & inhibitors
Pteridines--pharmacology
Rho Guanine Nucleotide Exchange Factors
Spindle Apparatus--drug effects
rhoA GTP-Binding Protein--metabolism
Polo-Like Kinase 1