Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. [electronic resource]
Producer: 20070523Description: 3853-61 p. digitalISSN:- 0008-5472
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Cell Growth Processes -- drug effects
- Cell Line, Tumor
- Curcumin -- administration & dosage
- Cyclooxygenase 2 -- biosynthesis
- Deoxycytidine -- administration & dosage
- Down-Regulation -- drug effects
- Drug Synergism
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Male
- Matrix Metalloproteinase 9 -- biosynthesis
- Mice
- NF-kappa B -- antagonists & inhibitors
- Neovascularization, Pathologic -- drug therapy
- Pancreatic Neoplasms -- blood supply
- Vascular Endothelial Growth Factor A -- biosynthesis
- Xenograft Model Antitumor Assays
- Gemcitabine
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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