Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

Kunnumakkara, Ajaikumar B

Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. [electronic resource] - Cancer research Apr 2007 - 3853-61 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0008-5472

10.1158/0008-5472.CAN-06-4257 doi


Animals
Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Cell Growth Processes--drug effects
Cell Line, Tumor
Curcumin--administration & dosage
Cyclooxygenase 2--biosynthesis
Deoxycytidine--administration & dosage
Down-Regulation--drug effects
Drug Synergism
Gene Expression Regulation, Neoplastic--drug effects
Humans
Male
Matrix Metalloproteinase 9--biosynthesis
Mice
NF-kappa B--antagonists & inhibitors
Neovascularization, Pathologic--drug therapy
Pancreatic Neoplasms--blood supply
Vascular Endothelial Growth Factor A--biosynthesis
Xenograft Model Antitumor Assays
Gemcitabine