Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. [electronic resource]
Producer: 20070706Description: 2399-407 p. digitalISSN:- 0022-2623
- Amides -- chemical synthesis
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- antagonists & inhibitors
- Animals
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Binding Sites
- CHO Cells
- Cricetinae
- Cricetulus
- Crystallography, X-Ray
- Dipeptides -- chemistry
- Drug Design
- Female
- Ligands
- Mice
- Mice, Transgenic
- Models, Molecular
- Molecular Structure
- Peptide Fragments -- antagonists & inhibitors
- Phthalic Acids -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
- Sulfonamides -- chemical synthesis
- Valine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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