Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Ghosh, Arun K
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. [electronic resource] - Journal of medicinal chemistry May 2007 - 2399-407 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0022-2623
10.1021/jm061338s doi
Amides--chemical synthesis
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Peptides--antagonists & inhibitors
Animals
Aspartic Acid Endopeptidases--antagonists & inhibitors
Binding Sites
CHO Cells
Cricetinae
Cricetulus
Crystallography, X-Ray
Dipeptides--chemistry
Drug Design
Female
Ligands
Mice
Mice, Transgenic
Models, Molecular
Molecular Structure
Peptide Fragments--antagonists & inhibitors
Phthalic Acids--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Valine--analogs & derivatives
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. [electronic resource] - Journal of medicinal chemistry May 2007 - 2399-407 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0022-2623
10.1021/jm061338s doi
Amides--chemical synthesis
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Peptides--antagonists & inhibitors
Animals
Aspartic Acid Endopeptidases--antagonists & inhibitors
Binding Sites
CHO Cells
Cricetinae
Cricetulus
Crystallography, X-Ray
Dipeptides--chemistry
Drug Design
Female
Ligands
Mice
Mice, Transgenic
Models, Molecular
Molecular Structure
Peptide Fragments--antagonists & inhibitors
Phthalic Acids--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Valine--analogs & derivatives