Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis. [electronic resource]
Producer: 20070622Description: 211-23 p. digitalISSN:- 0731-7085
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Autoanalysis
- Biological Assay
- Chromatography, Liquid -- methods
- Cytochrome P-450 CYP1A2 -- chemistry
- Cytochrome P-450 CYP1A2 Inhibitors
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP2D6 -- chemistry
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- chemistry
- Enzyme Inhibitors -- pharmacology
- Humans
- Inhibitory Concentration 50
- Isoenzymes -- antagonists & inhibitors
- Kinetics
- Microsomes, Liver -- enzymology
- Mixed Function Oxygenases -- antagonists & inhibitors
- Molecular Structure
- Reproducibility of Results
- Substrate Specificity
- Tandem Mass Spectrometry -- methods
No physical items for this record
Publication Type: Journal Article
There are no comments on this title.
Log in to your account to post a comment.