TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. [electronic resource]
Producer: 20070619Description: 4284-95 p. digitalISSN:- 0022-1767
- Cell Nucleus -- chemistry
- DNA -- chemistry
- Electrophoretic Mobility Shift Assay
- Epithelial Cells -- drug effects
- Gene Expression Regulation
- Humans
- Interferon-gamma -- antagonists & inhibitors
- MAP Kinase Kinase 4 -- metabolism
- Macrophages -- drug effects
- Methylation
- Monocytes -- drug effects
- Phosphorylation
- Protein Inhibitors of Activated STAT -- metabolism
- STAT1 Transcription Factor -- analysis
- Signal Transduction -- drug effects
- Smad Proteins -- metabolism
- Small Ubiquitin-Related Modifier Proteins -- metabolism
- Transcription, Genetic -- drug effects
- Transforming Growth Factor beta -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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