TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages.
Reardon, Colin
TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Apr 2007 - 4284-95 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-1767
10.4049/jimmunol.178.7.4284 doi
Cell Nucleus--chemistry
DNA--chemistry
Electrophoretic Mobility Shift Assay
Epithelial Cells--drug effects
Gene Expression Regulation
Humans
Interferon-gamma--antagonists & inhibitors
MAP Kinase Kinase 4--metabolism
Macrophages--drug effects
Methylation
Monocytes--drug effects
Phosphorylation
Protein Inhibitors of Activated STAT--metabolism
STAT1 Transcription Factor--analysis
Signal Transduction--drug effects
Smad Proteins--metabolism
Small Ubiquitin-Related Modifier Proteins--metabolism
Transcription, Genetic--drug effects
Transforming Growth Factor beta--pharmacology
TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Apr 2007 - 4284-95 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-1767
10.4049/jimmunol.178.7.4284 doi
Cell Nucleus--chemistry
DNA--chemistry
Electrophoretic Mobility Shift Assay
Epithelial Cells--drug effects
Gene Expression Regulation
Humans
Interferon-gamma--antagonists & inhibitors
MAP Kinase Kinase 4--metabolism
Macrophages--drug effects
Methylation
Monocytes--drug effects
Phosphorylation
Protein Inhibitors of Activated STAT--metabolism
STAT1 Transcription Factor--analysis
Signal Transduction--drug effects
Smad Proteins--metabolism
Small Ubiquitin-Related Modifier Proteins--metabolism
Transcription, Genetic--drug effects
Transforming Growth Factor beta--pharmacology