Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. [electronic resource]
Producer: 20070515Description: 735-41 p. digitalISSN:- 0009-9236
- Adult
- Area Under Curve
- Clopidogrel
- Cross-Over Studies
- Cytochrome P-450 CYP3A Inhibitors
- Double-Blind Method
- Drug Interactions
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Ketoconazole -- pharmacology
- Male
- Middle Aged
- Piperazines -- administration & dosage
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- administration & dosage
- Prasugrel Hydrochloride
- Thiophenes -- administration & dosage
- Ticlopidine -- administration & dosage
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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