Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.

Farid, N A

Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. [electronic resource] - Clinical pharmacology and therapeutics May 2007 - 735-41 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

0009-9236

10.1038/sj.clpt.6100139 doi


Adult
Area Under Curve
Clopidogrel
Cross-Over Studies
Cytochrome P-450 CYP3A Inhibitors
Double-Blind Method
Drug Interactions
Enzyme Inhibitors--pharmacology
Female
Humans
Ketoconazole--pharmacology
Male
Middle Aged
Piperazines--administration & dosage
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--administration & dosage
Prasugrel Hydrochloride
Thiophenes--administration & dosage
Ticlopidine--administration & dosage