Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. [electronic resource]
Producer: 20070109Description: 1415-23 p. digitalISSN:- 1465-7392
- Animals
- Cerebellar Neoplasms -- genetics
- Cerebellum -- cytology
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Hedgehog Proteins -- metabolism
- Humans
- Kruppel-Like Transcription Factors -- genetics
- Medulloblastoma -- genetics
- Membrane Proteins -- metabolism
- Mice
- Nerve Tissue Proteins -- metabolism
- Protein Processing, Post-Translational
- RNA, Messenger -- genetics
- Repressor Proteins -- metabolism
- Signal Transduction
- Stem Cells -- cytology
- Transcription Factors -- genetics
- Ubiquitin-Protein Ligases -- metabolism
- Ubiquitins -- metabolism
- Zinc Finger Protein GLI1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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