Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
Di Marcotullio, Lucia
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. [electronic resource] - Nature cell biology Dec 2006 - 1415-23 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1465-7392
10.1038/ncb1510 doi
Animals
Cerebellar Neoplasms--genetics
Cerebellum--cytology
Down-Regulation
Gene Expression Regulation, Neoplastic
Hedgehog Proteins--metabolism
Humans
Kruppel-Like Transcription Factors--genetics
Medulloblastoma--genetics
Membrane Proteins--metabolism
Mice
Nerve Tissue Proteins--metabolism
Protein Processing, Post-Translational
RNA, Messenger--genetics
Repressor Proteins--metabolism
Signal Transduction
Stem Cells--cytology
Transcription Factors--genetics
Ubiquitin-Protein Ligases--metabolism
Ubiquitins--metabolism
Zinc Finger Protein GLI1
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. [electronic resource] - Nature cell biology Dec 2006 - 1415-23 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1465-7392
10.1038/ncb1510 doi
Animals
Cerebellar Neoplasms--genetics
Cerebellum--cytology
Down-Regulation
Gene Expression Regulation, Neoplastic
Hedgehog Proteins--metabolism
Humans
Kruppel-Like Transcription Factors--genetics
Medulloblastoma--genetics
Membrane Proteins--metabolism
Mice
Nerve Tissue Proteins--metabolism
Protein Processing, Post-Translational
RNA, Messenger--genetics
Repressor Proteins--metabolism
Signal Transduction
Stem Cells--cytology
Transcription Factors--genetics
Ubiquitin-Protein Ligases--metabolism
Ubiquitins--metabolism
Zinc Finger Protein GLI1