Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis. [electronic resource]
Producer: 20061102Description: 63-72 p. digitalISSN:- 0022-3565
- 3',5'-Cyclic-AMP Phosphodiesterases -- antagonists & inhibitors
- Animals
- Body Weight -- drug effects
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Encephalomyelitis, Autoimmune, Experimental -- prevention & control
- Glial Fibrillary Acidic Protein -- analysis
- Lipopolysaccharides -- pharmacology
- Mice
- Mice, Inbred C57BL
- Multiple Sclerosis -- drug therapy
- Phosphodiesterase Inhibitors -- therapeutic use
- Proto-Oncogene Proteins c-fos -- analysis
- Pyridines -- therapeutic use
- Rolipram -- therapeutic use
- Spinal Cord -- pathology
- Tumor Necrosis Factor-alpha -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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