Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis. (Record no. 16402269)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01999 a2200481 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515032522.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200611s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0022-3565 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1124/jpet.106.106096 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Moore, C S |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20061102 |
| 245 00 - TITLE STATEMENT | |
| Title | Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | The Journal of pharmacology and experimental therapeutics |
| Date of publication, distribution, etc. | Oct 2006 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 63-72 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | 3',5'-Cyclic-AMP Phosphodiesterases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Body Weight |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cyclic Nucleotide Phosphodiesterases, Type 4 |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Encephalomyelitis, Autoimmune, Experimental |
| General subdivision | prevention & control |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Glial Fibrillary Acidic Protein |
| General subdivision | analysis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Lipopolysaccharides |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Inbred C57BL |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Multiple Sclerosis |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phosphodiesterase Inhibitors |
| General subdivision | therapeutic use |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Proto-Oncogene Proteins c-fos |
| General subdivision | analysis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridines |
| General subdivision | therapeutic use |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rolipram |
| General subdivision | therapeutic use |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Spinal Cord |
| General subdivision | pathology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tumor Necrosis Factor-alpha |
| General subdivision | biosynthesis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Earl, N |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Frenette, R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Styhler, A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mancini, J A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nicholson, D W |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hebb, A L O |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Owens, T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Robertson, G S |
| 773 0# - HOST ITEM ENTRY | |
| Title | The Journal of pharmacology and experimental therapeutics |
| Related parts | vol. 319 |
| -- | no. 1 |
| -- | p. 63-72 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1124/jpet.106.106096">https://doi.org/10.1124/jpet.106.106096</a> |
| Public note | Available from publisher's website |
No items available.