Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer. [electronic resource]
Producer: 20070727Description: 33-47 p. digitalISSN:- 0167-6806
- Apoptosis -- drug effects
- Boronic Acids -- pharmacology
- Bortezomib
- Breast Neoplasms -- enzymology
- Cell Cycle Proteins -- metabolism
- Cell Line, Transformed
- Cell Line, Tumor
- Dual Specificity Phosphatase 1
- Female
- Humans
- Immediate-Early Proteins -- metabolism
- Phosphoprotein Phosphatases -- metabolism
- Protease Inhibitors -- pharmacology
- Protein Phosphatase 1
- Protein Tyrosine Phosphatases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyrazines -- pharmacology
- p38 Mitogen-Activated Protein Kinases -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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