In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy. [electronic resource]
Producer: 20060816Description: 193-202 p. digitalISSN:- 0022-3042
- Analysis of Variance
- Animals
- Animals, Newborn
- Blotting, Western -- methods
- Cell Survival -- drug effects
- Cells, Cultured
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- therapeutic use
- Evaluation Studies as Topic
- Gene Expression -- drug effects
- Hippocampus -- drug effects
- Histone Deacetylase Inhibitors
- In Vitro Techniques
- Motor Neurons -- drug effects
- Muscular Atrophy, Spinal -- drug therapy
- Nerve Tissue Proteins -- metabolism
- RNA-Binding Proteins -- metabolism
- Rats
- SMN Complex Proteins
- Survival of Motor Neuron 1 Protein
- Survival of Motor Neuron 2 Protein
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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