In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy.

Hahnen, Eric

In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy. [electronic resource] - Journal of neurochemistry Jul 2006 - 193-202 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0022-3042

10.1111/j.1471-4159.2006.03868.x doi


Analysis of Variance
Animals
Animals, Newborn
Blotting, Western--methods
Cell Survival--drug effects
Cells, Cultured
Cyclic AMP Response Element-Binding Protein--metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Enzyme Inhibitors--therapeutic use
Evaluation Studies as Topic
Gene Expression--drug effects
Hippocampus--drug effects
Histone Deacetylase Inhibitors
In Vitro Techniques
Motor Neurons--drug effects
Muscular Atrophy, Spinal--drug therapy
Nerve Tissue Proteins--metabolism
RNA-Binding Proteins--metabolism
Rats
SMN Complex Proteins
Survival of Motor Neuron 1 Protein
Survival of Motor Neuron 2 Protein