EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. [electronic resource]
Producer: 20061109Description: 6497-509 p. digitalISSN:- 0950-9232
- Adaptor Proteins, Signal Transducing -- metabolism
- Animals
- CHO Cells
- Cell Survival -- drug effects
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cricetinae
- Down-Regulation
- ErbB Receptors -- metabolism
- Humans
- Mice
- NIH 3T3 Cells
- Protein Binding
- Protein Processing, Post-Translational
- Proto-Oncogene Proteins c-cbl -- metabolism
- Quinazolines
- Transfection
- Tyrphostins -- pharmacology
- Ubiquitin -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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