EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.

Davies, G C

EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. [electronic resource] - Oncogene Oct 2006 - 6497-509 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

0950-9232

10.1038/sj.onc.1209662 doi


Adaptor Proteins, Signal Transducing--metabolism
Animals
CHO Cells
Cell Survival--drug effects
Cell Transformation, Neoplastic
Cells, Cultured
Cricetinae
Down-Regulation
ErbB Receptors--metabolism
Humans
Mice
NIH 3T3 Cells
Protein Binding
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-cbl--metabolism
Quinazolines
Transfection
Tyrphostins--pharmacology
Ubiquitin--metabolism