Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. [electronic resource]
Producer: 20060811Description: 454-64 p. digitalISSN:- 0014-4886
- Animals
- Behavior, Animal -- drug effects
- Blotting, Western -- methods
- Brain -- drug effects
- Brain Injuries -- drug therapy
- Cell Survival -- drug effects
- Complement System Proteins -- genetics
- Disease Models, Animal
- Gene Expression -- drug effects
- Immunohistochemistry -- methods
- Male
- Mice
- Mice, Inbred C57BL
- Neurons -- drug effects
- Neuroprotective Agents -- administration & dosage
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Psychomotor Performance -- drug effects
- RNA, Messenger -- metabolism
- Receptors, Complement -- administration & dosage
- Receptors, Complement 3b
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- Time Factors
- Trauma Severity Indices
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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