Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.
Leinhase, Iris
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. [electronic resource] - Experimental neurology Jun 2006 - 454-64 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0014-4886
10.1016/j.expneurol.2006.01.033 doi
Animals
Behavior, Animal--drug effects
Blotting, Western--methods
Brain--drug effects
Brain Injuries--drug therapy
Cell Survival--drug effects
Complement System Proteins--genetics
Disease Models, Animal
Gene Expression--drug effects
Immunohistochemistry--methods
Male
Mice
Mice, Inbred C57BL
Neurons--drug effects
Neuroprotective Agents--administration & dosage
Proto-Oncogene Proteins c-bcl-2--genetics
Psychomotor Performance--drug effects
RNA, Messenger--metabolism
Receptors, Complement--administration & dosage
Receptors, Complement 3b
Reverse Transcriptase Polymerase Chain Reaction--methods
Time Factors
Trauma Severity Indices
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. [electronic resource] - Experimental neurology Jun 2006 - 454-64 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0014-4886
10.1016/j.expneurol.2006.01.033 doi
Animals
Behavior, Animal--drug effects
Blotting, Western--methods
Brain--drug effects
Brain Injuries--drug therapy
Cell Survival--drug effects
Complement System Proteins--genetics
Disease Models, Animal
Gene Expression--drug effects
Immunohistochemistry--methods
Male
Mice
Mice, Inbred C57BL
Neurons--drug effects
Neuroprotective Agents--administration & dosage
Proto-Oncogene Proteins c-bcl-2--genetics
Psychomotor Performance--drug effects
RNA, Messenger--metabolism
Receptors, Complement--administration & dosage
Receptors, Complement 3b
Reverse Transcriptase Polymerase Chain Reaction--methods
Time Factors
Trauma Severity Indices